When the tumor is in the process of development, the normal tissue around the lesion will appear inflamed and produce many different molecules, including two related proteins, interleukin-11 and interleukin-6. These hormone-like signaling molecules are collectively called cytokines and are considered to be important substances that promote the growth and spread of cancer cells. But the former has always been considered to play only a small role in it.
However, researchers Tracy Paboski and Matthias Ernst of the Walter Eliza Institute of Medicine in Australia found that interleukin-11 is the most important cytokine to promote the growth and spread of cancer cells . Working with CSL Pharmaceuticals in Melbourne, Australia, they found that blocking the signal of interleukin-11 can stop tumor growth and shrink the tumor in gastric and intestinal cancer models. This is expected to bring a new approach to the treatment of bowel cancer and stomach cancer, and these two cancers are also the two most common cancers in the world.
Pabosky said: "When considering the cytokines that promote the growth and development of cancer cells, people often think of interleukin-6 first, and interleukin-11, which is very similar to it, is ignored. This new study found , The latter is actually the most important carcinogen. "
Associate Professor Ernst pointed out that the treatment of cancer by blocking cytokine signals is an exciting new therapy that has many potential advantages over existing therapies. CSL Pharmaceuticals is also optimistic about the prospects of interleukin-11 related drugs. Its senior vice president announced that they have developed some candidate drugs for interleukin-11 receptors, which are expected to play a role in the treatment of gastric cancer and intestinal cancer. effect.
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